Achieving adherent culture scale-up technology

The final decision between the adherent and the suspension cell culture platform is often made by therapy developers to increase the activity to meet the demand. Depending on the type of phone, time, required output, location and function, cost, and other considerations, each has advantages and disadvantages.

Encouraging culture-enhancing technology with collaborative R&D.Image Credit: Shutterstock.com/Billion Photos

A system that combines the productivity benefits of adherent cell culture with the scalability, automation, and control of a release system is the ultimate strategy for some applications.

For several years, the Corning Research and Development company has been using its innovative process to meet these requirements. Customer relationship is the first step in this process, which involves working with customers to understand their problems, pains and goals.

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Corning field research experts, sales representatives, and scientific support companies gather intelligence and discuss product-related ideas and bottlenecks. To create the right solutions, they then draw on Corning’s years of scientific expertise and deep knowledge of cell biology and behavior.

The production of the Corning® Up® The FBR System is the latest iteration of this collaborative approach. This fixed bed bioreactor was developed to solve the problems of producing large amounts of adherent cells to support drugs.

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It is intended to provide wide-area dynamics and high-throughput bioproduction capabilities in a platform that extends from benchtop process development to commercial production. Customer feedback during alpha and beta testing resulted in significant design changes, resulting in a more robust system featuring an integrated controller, media conditioning vessel, bioreactor vessel, and sensors.

For Corning Life Sciences

A division of Corning Incorporated, Corning Life Sciences is a leading global manufacturer of cell culture products and solutions that enable scientists in academia, biotech and biopharma to harness the power of cells to make things. again to change life. Corning supports application areas such as core cell culture, 3D cell culture, bioprocess, cancer research, primary and stem cell research, drug screening, cell and gene therapy, disease modeling, lab automation and more.

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Your goal is cell expansion or viral vector production, Corning Life Sciences platforms, with HYPERStack® vessels to increase the growth of cells in a small footprint, high altitude® Bed Reactor platforms, microcarriers, and closed systems can help you there. Choose from hundreds of vessels, the widest selection of cell culture plates, and custom media in a variety of single-use technical setups. Learn more at www.corning.com/lifesciences.

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